Name | Lipid peroxidation inhibitor 1 |
Synonyms | 142873-41-4 Lipid peroxidation inhibitor 1 5-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]- |
CAS | 142873-41-4 |
Molecular Formula | C24H32N2O |
Molar Mass | 364.52368 |
Density | 1.090±0.06 g/cm3(Predicted) |
Boling Point | 520.4±50.0 °C(Predicted) |
pKa | 8.09±0.10(Predicted) |
Storage Condition | -20°C,干燥,密封 |
In vitro study | Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC 50 of 0.07 μM. |
In vivo study | Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective. |